The Hatsopoulos Microfluids laboratory (HML) was created within the Department of Mechanical Engineering as a center for research activities which focus on understanding the dynamics of fluid with microstructure and the emerging science of microfluidics. The HML consists of a single open-plan 6,300 ft² laboratory that houses seven active faculty plus over 45 students and postdoctoral researchers. A broad overview of the principal research areas of faculty members within the laboratory is summarized below:

—Optical imaging of complex flows
—Rheology and dynamics of complex fluids
—Dynamics of thin films
—Flow stability
—Flow-structure interactions
—Flow in microfluidic devices and 'lab-on-a-chip' applications
—Biofluid mechanics and biorheology
—Capillary phenomena and contact line dynamics